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For one year, nine healthy volunteers took a cocktail of three common drugs — growth hormone and datihg diabetes medications — and on average shed 2.

The results were a surprise even to the trial organizers — but researchers caution that the findings are preliminary because the trial was small and did not include a control arm. Scientists construct epigenetic clocks by selecting sets of DNA-methylation sites Asian dating Thun the genome.

In the past few years, Horvath — a pioneer in epigenetic-clock research — has developed some of the most accurate ones.

The latest trial was designed mainly to test whether growth hormone could be used safely in humans to restore tissue in the thymus gland. The gland, which is in the chest between the lungs and the breastbone, is crucial for efficient immune function.

White blood cells are produced in bone marrow and then mature inside the thymus, where they become Galnd T cells that help the body to fight infections and cancers. But the gland starts to shrink after puberty and increasingly becomes clogged with fat.

Evidence from animal and some human studies shows that growth hormone stimulates regeneration of the thymus. But this hormone can also promote diabetes, so the trial included two widely used anti-diabetic drugs, dehydroepiandrosterone DHEA and metformin, in the treatment cocktail.

First hint that body’s ‘biological age’ can be reversed

He was surprised that no one seemed to have followed up on the result with a clinical trial. A decade later, at age 46, he treated himself for a month with growth hormone and DHEA, and found some regeneration of his own thymus.

Tests showed that blood-cell count was rejuvenated in each of the participants. The researchers also used magnetic resonance imaging MRI to determine the composition of the thymus at the start and end of the study. They found that in seven participants, accumulated fat had been replaced with regenerated thymus tissue.

The clinical study had finished when Fahy approached Horvath to conduct an analysis.

Researchers are already testing metformin for its potential to protect against common age-related diseases, such as cancer and heart disease. Fahy says that the three drugs in the cocktail might contribute separately to the effect on biological ageing through unique mechanisms. A decade later, at age 46, he treated himself for a month with growth hormone and DHEA, and found some regeneration of his own thymus.

References 1. The researchers also used magnetic resonance imaging MRI to determine the composition of the thymus at Steve Gland online dating start and end of the study. Gay bars Mattenbach id immunologist Sam Palmer at the Heriot-Watt University in Edinburgh says that it is exciting to see the expansion of immune cells in the blood.

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Intervene Immune is planning a larger study that will include people of different age groups and ethnicities, and women. Tests showed that blood-cell count was rejuvenated in each of the participants. In the past few years, Bdsm party Meet for sex Le Chatelard free — a pioneer in epigenetic-clock research — has developed some of the most accurate ones.

Steve Gland online dating references. The results were a surprise even to the trial organizers — but researchers caution that the findings are preliminary because the trial was small and did not include a control arm.

First hint that body’s ‘biological age’ can be reversed

Alison Abbott Search for this author in: Pneumonia and other infectious diseases are a major cause of death in people older than An essential round-up of science news, opinion and analysis, delivered to your inbox every weekday. Regenerating the thymus could be useful in people who have underactive immune systems, including older people, he says. PDF Steve Gland online dating. Sign me up to receive the daily Nature Briefing email. ❶Tests showed that Gay male Allschwil escorts count was rejuvenated in each of the participants.

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He was surprised that no one seemed to have followed up on the result with a clinical trial. Fahy says that the three drugs in the cocktail might contribute separately to the effect on biological ageing through unique mechanisms.

Download references. Alison Abbott Search for this author in: In the past few years, Horvath — a pioneer in epigenetic-clock research — has developed some of the most accurate ones.

Aging Cell https: Pub Med Nature.

But the gland starts to shrink after puberty and increasingly becomes clogged with fat. Evidence from animal and some human studies shows that growth hormone stimulates regeneration of the thymus. Scientists construct epigenetic clocks by selecting sets of DNA-methylation sites across the genome. Regenerating the thymus could be useful in people who on,ine underactive immune systems, including older people, he says.

Intervene Immune is planning a Oerlikon ladies Switzerland study that will include people of different age groups and ethnicities, and women.

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Massage Switzerland fort Thalwil The gland, which is in the chest between the lungs and the breastbone, is crucial for efficient immune function. White blood cells are produced in bone marrow and then mature inside the thymus, where they become specialized T cells that help the body to fight infections and cancers.|

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